WHSC1 Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform 2 may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - lysine degradation; EC; Methyltransferase; Methyltransferase, protein lysine; Oncoprotein; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 5|5 B2
Cellular Component:  chromatin; chromosome; nucleus
Molecular Function:  chromatin binding; DNA binding; histone methyltransferase activity (H3-K36 specific); histone-lysine N-methyltransferase activity; metal ion binding; methyltransferase activity; protein binding; sequence-specific DNA binding; transferase activity
Biological Process:  atrial septum primum morphogenesis; atrial septum secundum morphogenesis; bone development; chromatin organization; histone H3-K36 methylation; histone H4-K20 methylation; membranous septum morphogenesis; methylation; negative regulation of transcription by RNA polymerase II; positive regulation of isotype switching to IgA isotypes; regulation of double-strand break repair via nonhomologous end joining; regulation of establishment of protein localization; regulation of transcription, DNA-templated
Reference #:  Q8BVE8 (UniProtKB)
Alt. Names/Synonyms: 5830445G22Rik; 9430010A17Rik; AW555663; C130020C13Rik; D030027O06Rik; D930023B08Rik; Histone-lysine N-methyltransferase NSD2; IL5 promoter REII region-binding protein; Kiaa1090; mKIAA1090; Nsd2; nuclear receptor binding SET domain protein 2; Nuclear SET domain-containing protein 2; Probable histone-lysine N-methyltransferase NSD2; trithorax/ash1-related protein 5; Whsc1; Whsc1l; Wolf-Hirschhorn syndrome candidate 1 (human); Wolf-Hirschhorn syndrome candidate 1 protein homolog; Wolf-Hirschhorn syndrome candidate 1-like
Gene Symbols: Nsd2
Molecular weight: 152,253 Da
Basal Isoelectric point: 8.86  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene