CDK13 a CMGC protein kinase of the CDK family. It has been reported to interact with L-type cyclins. Overexpression of CDC2L5 constructs disturbs constitutive splicing and switches alternative splice site selection in vivo suggesting that it may regulate alternative splicing. It has unusually large N- and C-termini and is ubiquitously expressed in many tissues. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/CRK7 subfamily; CMGC group; CRK7 subfamily; Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); RNA splicing
Chromosomal Location of Human Ortholog: 13|13 A2
Cellular Component:  chromosome; cyclin K-CDK13 complex; cyclin-dependent protein kinase holoenzyme complex; cyclin/CDK positive transcription elongation factor complex; cytosol; Golgi apparatus; nuclear chromatin; nuclear cyclin-dependent protein kinase holoenzyme complex; nuclear speck; nucleus
Molecular Function:  ATP binding; cyclin binding; cyclin-dependent protein serine/threonine kinase activity; kinase activity; nucleotide binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; RNA polymerase II CTD heptapeptide repeat kinase activity; transcription factor binding; transcription regulatory region DNA binding; transferase activity
Biological Process:  alternative mRNA splicing, via spliceosome; hemopoiesis; mRNA processing; negative regulation of stem cell differentiation; phosphorylation; phosphorylation of RNA polymerase II C-terminal domain; positive regulation of transcription by RNA polymerase II; positive regulation of transcription elongation from RNA polymerase II promoter; protein phosphorylation; RNA splicing; transcription elongation from RNA polymerase II promoter
Reference #:  Q69ZA1 (UniProtKB)
Alt. Names/Synonyms: 2310015O17Rik; CDC2-related protein kinase 5; Cdc2l5; Cdk13; cell division cycle 2-like 5 (cholinesterase-related cell division controller); Cell division cycle 2-like protein kinase 5; Cell division protein kinase 13; CHED; Cyclin-dependent kinase 13; Kiaa1791
Gene Symbols: Cdk13
Molecular weight: 164,553 Da
Basal Isoelectric point: 9.7  Predict pI for various phosphorylation states
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CDK13

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein