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Abi-1
an SH3-containing adapter protein that regulates c-Abl-mediated phosphorylation of Mena. Binds the SH3 domains of epidermal growth factor receptor kinase substrate (EPS8) and of spectrin. May play a role in fusion of macropinocytic vesicles. Associated with congenital acute monocytic leukemia. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of Human Ortholog: 2 A3|2 15.18 cM |
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Cellular Component:
cell junction; cell leading edge; cell projection; cytoplasm; cytoskeleton; filopodium tip; glutamatergic synapse; lamellipodium; membrane; neuron projection; nucleus; plasma membrane; postsynaptic density; postsynaptic membrane; SCAR complex; synapse
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Molecular Function:
protein binding; protein tyrosine kinase activator activity; SH3 domain binding; transcription factor binding
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Biological Process:
actin polymerization or depolymerization; dendrite morphogenesis; lamellipodium morphogenesis; megakaryocyte development; peptidyl-tyrosine phosphorylation; postsynapse to nucleus signaling pathway; somitogenesis
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Reference #:
Q8CBW3
(UniProtKB)
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Alt. Names/Synonyms: Abelson interactor 1; Abi-1; Abi1; Abl interactor 1; abl-interactor 1; Ablphilin-1; e3B1; eps8 binding protein; Eps8 SH3 domain-binding protein; Eps8-binding protein; MGC6064; NAP1; spectrin SH3 domain binding protein 1; Spectrin SH3 domain-binding protein 1; Ssh3bp1
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Gene Symbols: Abi1
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Molecular weight:
52,288 Da
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Basal Isoelectric point:
7.16
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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