Abi-1 an SH3-containing adapter protein that regulates c-Abl-mediated phosphorylation of Mena. Binds the SH3 domains of epidermal growth factor receptor kinase substrate (EPS8) and of spectrin. May play a role in fusion of macropinocytic vesicles. Associated with congenital acute monocytic leukemia. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2 A3|2 15.18 cM
Cellular Component:  cell junction; cell leading edge; cell projection; cytoplasm; cytoskeleton; filopodium tip; glutamatergic synapse; lamellipodium; membrane; neuron projection; nucleus; plasma membrane; postsynaptic density; postsynaptic membrane; SCAR complex; synapse
Molecular Function:  protein binding; protein tyrosine kinase activator activity; SH3 domain binding; transcription factor binding
Biological Process:  actin polymerization or depolymerization; dendrite morphogenesis; lamellipodium morphogenesis; megakaryocyte development; peptidyl-tyrosine phosphorylation; postsynapse to nucleus signaling pathway; somitogenesis
Reference #:  Q8CBW3 (UniProtKB)
Alt. Names/Synonyms: Abelson interactor 1; Abi-1; Abi1; Abl interactor 1; abl-interactor 1; Ablphilin-1; e3B1; eps8 binding protein; Eps8 SH3 domain-binding protein; Eps8-binding protein; MGC6064; NAP1; spectrin SH3 domain binding protein 1; Spectrin SH3 domain-binding protein 1; Ssh3bp1
Gene Symbols: Abi1
Molecular weight: 52,288 Da
Basal Isoelectric point: 7.16  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene