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Abi-1
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. Belongs to the ABI family. Widely expressed, with highest expression in brain. 12 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 2 A3|2 15.18 cM |
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Cellular Component:
cell leading edge; cell projection; cytoplasm; cytoskeleton; filopodium tip; glutamatergic synapse; intracellular anatomical structure; lamellipodium; neuron projection; nucleus; postsynaptic density; SCAR complex; synapse
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Molecular Function:
protein binding; protein tyrosine kinase activator activity; SH3 domain binding; signaling adaptor activity
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Biological Process:
dendrite morphogenesis; lamellipodium morphogenesis; megakaryocyte development; positive regulation of protein tyrosine kinase activity; postsynapse to nucleus signaling pathway; somitogenesis
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Reference #:
Q8CBW3
(UniProtKB)
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Alt. Names/Synonyms: Abelson interactor 1; Abi-1; Abi1; Abl interactor 1; abl-interactor 1; Ablphilin-1; e3B1; eps8 binding protein; Eps8 SH3 domain-binding protein; Eps8-binding protein; MGC6064; NAP1; spectrin SH3 domain binding protein 1; Spectrin SH3 domain-binding protein 1; Ssh3; Ssh3bp1
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Gene Symbols: Abi1
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Molecular weight:
52,288 Da
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Basal Isoelectric point:
7.16
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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