ZO2 Plays a role in tight junctions and adherens junctions. Belongs to the MAGUK family. This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues. 7 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 19|19 B
Cellular Component:  bicellular tight junction; cell junction; cell surface; cell-cell junction; cytosol; gap junction; membrane; nucleoplasm; nucleus; plasma membrane; tight junction
Molecular Function:  protein binding; protein binding, bridging; protein C-terminus binding; protein domain specific binding
Biological Process:  establishment of endothelial intestinal barrier; intestinal absorption; negative regulation of osteoclast development; regulation of membrane permeability; TNFSF11-mediated signaling pathway
Reference #:  Q9Z0U1 (UniProtKB)
Alt. Names/Synonyms: Tight junction protein 2; Tight junction protein ZO-2; Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2); Tjp2; ZO-2; Zo2; Zona occludens protein 2; Zonula occludens protein 2
Gene Symbols: Tjp2
Molecular weight: 131,280 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene