ZO2
Plays a role in tight junctions and adherens junctions. Belongs to the MAGUK family. This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues. 7 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
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Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
Chromosomal Location of mouse Ortholog: 19|19 B |
Cellular Component:
anchoring junction; bicellular tight junction; cell junction; cell surface; cell-cell contact zone; cell-cell junction; gap junction; membrane; nucleus; plasma membrane; tight junction
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Molecular Function:
cell adhesion molecule binding; protein binding; protein domain specific binding; protein tyrosine kinase binding; protein-macromolecule adaptor activity; transmembrane transporter binding
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Biological Process:
cell-cell adhesion; cell-cell junction organization; establishment of endothelial intestinal barrier; homotypic cell-cell adhesion; intestinal absorption; negative regulation of osteoclast development; positive regulation of blood-brain barrier permeability; protein localization to cell-cell junction; regulation of membrane permeability; TNFSF11-mediated signaling pathway
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Reference #:
Q9Z0U1
(UniProtKB)
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Alt. Names/Synonyms: Tight junction protein 2; Tight junction protein ZO-2; Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2); Tjp2; ZO-; ZO-2; Zo2; Zona occludens protein 2; Zonula occludens protein 2
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Gene Symbols: Tjp2
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Molecular weight:
131,280 Da
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Basal Isoelectric point:
6.35
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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