SEPT2 Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. Widely expressed. Up-regulated in liver cancer. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cell development/differentiation; Cytoskeletal; Hydrolase; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1|1 D
Cellular Component:  actin cytoskeleton; actomyosin contractile ring; axoneme; cell cortex; cell projection; cell surface; chromosome; chromosome, centromeric region; ciliary membrane; ciliary transition zone; cilium; cytoplasm; cytoskeleton; exocyst; kinetochore; membrane; microtubule cytoskeleton; midbody; motile cilium; non-motile cilium; nucleus; perinuclear region of cytoplasm; photoreceptor connecting cilium; plasma membrane; septin complex; septin ring; sperm annulus; spindle microtubule; synapse
Molecular Function:  enzyme regulator activity; GTP binding; GTPase activity; identical protein binding; molecular adaptor activity; nucleotide binding; protein binding
Biological Process:  cell cycle; cell differentiation; cell division; cilium assembly; cytoskeleton-dependent cytokinesis; neuron projection development; protein polymerization; regulation of L-glutamate import across plasma membrane; regulation of protein localization; smoothened signaling pathway; spermatogenesis
Reference #:  P42208 (UniProtKB)
Alt. Names/Synonyms: AW208991; mKIAA0158; NEDD-5; Nedd5; Neural precursor cell expressed developmentally down-regulated protein 5; neural precursor cell expressed, developmentally down-regulated gene 5; OTTMUSP00000024480; Sept2; septin 2; Septin-2
Gene Symbols: Sept2
Molecular weight: 41,526 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene