PRP4 a kinase of the DYRK family associated with the spliceosome and the kinetochore. It binds pre-mRNA splicing factors SFRS8, PRP6 and pinin. It is an essential kinase that associates with both the U5 snRNP and the N-CoR deacetylase complexes. It may help coordinate pre-mRNA splicing with chromatin remodeling and transcriptional regulation. PRP4 has recently been shown to be a kinetochore component that is necessary to establish a functional spindle assembly checkpoint, and is necessary for recruitment or maintenance of the checkpoint proteins RPS27, MAD1, and MAD2 at the kinetochores. Note: This description may include information from UniProtKB.
Protein type: CMGC group; DYRK family; EC 2.7.11.1; Kinase, protein; PRP4 subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); RNA splicing; Spliceosome
Chromosomal Location of Human Ortholog: 13|13 A3.3
Cellular Component:  catalytic step 2 spliceosome; chromosome; nuclear speck; nucleus; spliceosomal complex
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  mRNA processing; phosphorylation; protein phosphorylation; RNA splicing
Reference #:  Q61136 (UniProtKB)
Alt. Names/Synonyms: 2610037H07; Cbp143; MGC5960; Pre-mRNA protein kinase; Prp4; PRP4 pre-mRNA processing factor 4 homolog B (yeast); PRP4 pre-mRNA-processing factor 4 homolog; PRP4B; Prp4h; Prp4k; Prp4m; Prpf4b; Prpk; Serine/threonine-protein kinase PRP4 homolog
Gene Symbols: Prpf4b
Molecular weight: 116,976 Da
Basal Isoelectric point: 10.23  Predict pI for various phosphorylation states
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PRP4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene