plakophilin 3 May play a role in junctional plaques. Belongs to the beta-catenin family. Isoform PKP3a is found in desmosomes of most simple and stratified epithelia. Not found in foreskin fibroblasts and various sarcoma-derived cell lines. Beside dendritic reticular cells of lymphatic follicles not found in non-epithelial desmosome-bearing tissues. Isoform PKP3b is abundant in the desmosomes of stratified epithelial cell but absent in simple epithelial cells, it is also expressed in the colon and its tumors. 2 human isoforms generated by alternative promoter usage have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion
Chromosomal Location of mouse Ortholog: 7|7 F5
Cellular Component:  cell junction; cell-cell adherens junction; cell-cell junction; cytoplasm; desmosome; messenger ribonucleoprotein complex; nucleoplasm; nucleus; plasma membrane; spot adherens junction
Molecular Function:  alpha-catenin binding; cadherin binding; cell adhesion molecule binding; enzyme binding; protein binding
Biological Process:  cell adhesion; cell-cell adhesion; cell-cell junction assembly; desmosome assembly; negative regulation of mRNA catabolic process; positive regulation of gene expression; protein localization to plasma membrane
Reference #:  Q9QY23 (UniProtKB)
Alt. Names/Synonyms: 2310056L12Rik; Pkp3; plakophilin 3; Plakophilin-3
Gene Symbols: Pkp3
Molecular weight: 87,333 Da
Basal Isoelectric point: 9.4  Predict pI for various phosphorylation states
Select Structure to View Below

plakophilin 3

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene