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MAP1B
Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. Belongs to the MAP1 family. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of rat Ortholog: 2q12 |
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Cellular Component:
apical dendrite; axon; basal dendrite; cytosol; dendrite; dendritic spine; growth cone; hippocampal mossy fiber; microtubule; microtubule associated complex; neuronal cell body; perikaryon; perinuclear region of cytoplasm; photoreceptor outer segment; plasma membrane; postsynaptic density; somatodendritic compartment; synapse; varicosity
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Molecular Function:
actin binding; microtubule binding; phospholipid binding; protein binding; protein-containing complex binding
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Biological Process:
axon extension; axonogenesis; cellular response to growth factor stimulus; cellular response to peptide hormone stimulus; dendrite development; developmental maturation; establishment of monopolar cell polarity; induction of synaptic plasticity by chemical substance; intracellular transport; microtubule bundle formation; microtubule cytoskeleton organization; mitochondrion transport along microtubule; negative regulation of intracellular transport; negative regulation of microtubule depolymerization; nervous system development; neuron development; neuron projection development; odontoblast differentiation; peripheral nervous system axon regeneration; positive regulation of axon extension; positive regulation of microtubule polymerization; positive regulation of neuron differentiation; regulation of microtubule depolymerization; response to axon injury; response to carbohydrate; response to estradiol; response to inorganic substance; response to insecticide; response to mechanical stimulus; response to nutrient levels; response to vitamin A; response to xenobiotic stimulus; synapse assembly
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Reference #:
P15205
(UniProtKB)
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Alt. Names/Synonyms: MAP-1B; MAP1 light chain LC1; Map1b; Microtubule-associated protein 1B; Mtap1b; Neuraxin
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Gene Symbols: Map1b
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Molecular weight:
269,643 Da
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Basal Isoelectric point:
4.74
Predict pI for various phosphorylation states
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CST Pathways:
Microtubule Dynamics
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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