MAP1B the function of brain MAPS is essentially unknown. Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B Binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 13 D1|13 52.9 cM
Cellular Component:  apical dendrite; axon; basal dendrite; cell junction; cell projection; cytoplasm; cytoskeleton; cytosol; dendrite; growth cone; hippocampal mossy fiber; microtubule; microtubule associated complex; neuronal cell body; perikaryon; perinuclear region of cytoplasm; photoreceptor outer segment; plasma membrane; postsynaptic density; somatodendritic compartment; synapse; varicosity
Molecular Function:  actin binding; cytoskeletal regulatory protein binding; microtubule binding; phospholipid binding; protein binding; protein-containing complex binding; tubulin binding
Biological Process:  axon extension; axonogenesis; cellular process; dendrite development; establishment of monopolar cell polarity; microtubule bundle formation; microtubule cytoskeleton organization; microtubule-based process; mitochondrion transport along microtubule; negative regulation of intracellular transport; negative regulation of microtubule depolymerization; nervous system development; positive regulation of axon extension; positive regulation of microtubule polymerization; positive regulation of neuron differentiation; regulation of microtubule depolymerization
Reference #:  P14873 (UniProtKB)
Alt. Names/Synonyms: A230055D22; AI843217; LC1; MAP-1B; MAP1 light chain LC1; MAP1(X); MAP1.2; Map1b; MAP5; MGC169657; MGC169658; Microtubule-associated protein 1B; Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)); microtubule-associated protein 5; Mtap-5; Mtap1b; Mtap5
Gene Symbols: Map1b
Molecular weight: 270,255 Da
Basal Isoelectric point: 4.76  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein