UBR5 E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ligase; Nuclear receptor co-regulator; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of rat Ortholog: 7q22
Cellular Component:  cytosol; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein-containing complex
Molecular Function:  protein domain specific binding; RNA binding; ubiquitin binding; ubiquitin protein ligase activity; ubiquitin-ubiquitin ligase activity; zinc ion binding
Biological Process:  cellular response to DNA damage stimulus; DNA repair; negative regulation of double-strand break repair; negative regulation of histone H2A K63-linked ubiquitination; negative regulation of interleukin-17 secretion; positive regulation of canonical Wnt signaling pathway; positive regulation of gene expression; positive regulation of protein import into nucleus; progesterone receptor signaling pathway; protein K48-linked ubiquitination; protein polyubiquitination; protein ubiquitination; regulation of protein stability
Reference #:  XP_001061308 (RefSeq)
Alt. Names/Synonyms: 100 kDa protein; Dd5; E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase, HECT domain-containing 1; Edd; Edd1; Hyd; Hyperplastic discs protein homolog; progestin induced protein; progestin-induced protein; Rat100; ubiquitin protein ligase E3 component n-recognin 5; Ubr5
Gene Symbols: Ubr5
Molecular weight: 307,256 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA