CTNND1 an Arm repeat protein that interacts with varied components such as cadherin, small G proteins, kinases, and the Kaiso transcriptional repressor. A downstream modulator of Wnt/beta-catenin signaling pathway whose stability may be regulated downstream of Dsh. Required for the invasiveness of E-cadherin-deficient cells. A signal coordinator between cadherins and Rho-family GTPases to regulate cytoskeletal changes required during dendritic spine and synapse development. The association of catenins with cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Thirty two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2 D|2 49.45 cM
Cellular Component:  bicellular tight junction; catenin complex; cell-cell adherens junction; cell-cell junction; cytoplasm; cytosol; dendritic spine; glutamatergic synapse; growth cone; hippocampal mossy fiber to CA3 synapse; lamellipodium; membrane; midbody; nucleus; plasma membrane; postsynaptic density, intracellular component; presynaptic active zone cytoplasmic component; Schaffer collateral - CA1 synapse; synapse; zonula adherens
Molecular Function:  cadherin binding; cell adhesion molecule binding; protein binding; protein domain specific binding; protein kinase binding; signaling receptor binding
Biological Process:  cell adhesion; cell-cell adhesion; cell-cell junction assembly; epithelial cell differentiation involved in salivary gland development; glomerulus morphogenesis; kidney development; morphogenesis of a polarized epithelium; negative regulation of canonical Wnt signaling pathway; positive regulation of peptidyl-tyrosine autophosphorylation; positive regulation of protein processing; regulation of postsynaptic membrane neurotransmitter receptor levels; salivary gland morphogenesis
Reference #:  P30999 (UniProtKB)
Alt. Names/Synonyms: AA409437; AU019353; Cadherin-associated Src substrate; CAS; catenin (cadherin associated protein), delta 1; Catenin delta-1; catenin src; Catns; CTND1; Ctnnd; Ctnnd1; Kiaa0384; mKIAA0384; OTTMUSP00000014428; OTTMUSP00000014429; P120; p120 catenin; p120(cas); p120(ctn); p120-catenin
Gene Symbols: Ctnnd1
Molecular weight: 104,925 Da
Basal Isoelectric point: 6.41  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene