CDK3 Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Expressed in cancer cell lines and glioblastoma tissue. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/CDK1 subfamily; CDK1 subfamily; CMGC group; Cell cycle regulation; EC 2.7.11.22; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 11|11 E2
Cellular Component:  nucleus
Molecular Function:  cyclin-dependent protein serine/threonine kinase activity
Biological Process:  protein phosphorylation
Reference #:  Q80YP0 (UniProtKB)
Alt. Names/Synonyms: 2310050O10Rik; Cdk3; Cell division protein kinase 3; Cyclin-dependent kinase 3
Gene Symbols: Cdk3
Molecular weight: 33,888 Da
Basal Isoelectric point: 9.08  Predict pI for various phosphorylation states
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CDK3

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Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene