CD2AP Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis. Plays a role in epithelial cell junctions formation. Widely expressed in fetal and adult tissues. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of rat Ortholog: 9q13
Cellular Component:  cell leading edge; cell-cell junction; cytoplasm; endocytic vesicle; filamentous actin; perinuclear region of cytoplasm; plasma membrane; protein-containing complex; ruffle
Molecular Function:  beta-catenin binding; cadherin binding; protein binding; protein C-terminus binding; protein-containing complex binding; SH3 domain binding; vascular endothelial growth factor receptor binding
Biological Process:  actin filament organization; cell division; cell migration; cell-cell adhesion; negative regulation of small GTPase mediated signal transduction; negative regulation of transforming growth factor beta1 production; positive regulation of protein localization to nucleus; positive regulation of protein secretion; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of actin cytoskeleton reorganization; regulation of receptor-mediated endocytosis; vesicle organization
Reference #:  F1LRS8 (UniProtKB)
Alt. Names/Synonyms: CD2-associated protein; Cd2ap; CMS
Gene Symbols: Cd2ap
Molecular weight: 70,491 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene