CD2AP an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Required for cytokinesis. Links CD2 engagement to the WASp-evoked actin polymerization required for synapse formation and T cell activation. Attaches to membrane proteins via its three SH3 domains and attaches to and rearranges the cytoskeleton via its C-terminus. CD2AP?s interactions with the cytoskeleton result in receptor clustering and endocysosis as well as targeting proteins to degradative vesicles in the kidney. Mice carrying a heterozygous knockout of CD2AP show defects in kidney filtration, and mutations in the human gene are associated with focal segmental glomerulosclerosis (FSGS3). Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q13
Cellular Component:  cell leading edge; cell-cell junction; cytoplasm; endocytic vesicle; filamentous actin; perinuclear region of cytoplasm; plasma membrane; protein-containing complex; ruffle
Molecular Function:  beta-catenin binding; cadherin binding; protein binding; protein C-terminus binding; protein-containing complex binding; SH3 domain binding; vascular endothelial growth factor receptor binding
Biological Process:  actin filament organization; cell division; cell migration; cell-cell adhesion; negative regulation of small GTPase mediated signal transduction; negative regulation of transforming growth factor beta1 production; positive regulation of protein localization to nucleus; positive regulation of protein secretion; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of actin cytoskeleton reorganization; regulation of receptor-mediated endocytosis; vesicle organization
Reference #:  F1LRS8 (UniProtKB)
Alt. Names/Synonyms: CD2-associated protein; Cd2ap; CMS
Gene Symbols: Cd2ap
Molecular weight: 70,491 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CD2AP

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene