CD2AP an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Required for cytokinesis. Links CD2 engagement to the WASp-evoked actin polymerization required for synapse formation and T cell activation. Attaches to membrane proteins via its three SH3 domains and attaches to and rearranges the cytoskeleton via its C-terminus. CD2AP?s interactions with the cytoskeleton result in receptor clustering and endocysosis as well as targeting proteins to degradative vesicles in the kidney. Mice carrying a heterozygous knockout of CD2AP show defects in kidney filtration, and mutations in the human gene are associated with focal segmental glomerulosclerosis (FSGS3). Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17|17 B3
Cellular Component:  cell cortex; cell junction; cell leading edge; cell projection; cytoplasm; cytoskeleton; endocytic vesicle; filamentous actin; intercellular junction; perinuclear region of cytoplasm; plasma membrane; ruffle
Molecular Function:  beta-catenin binding; cadherin binding; protein binding; protein C-terminus binding; SH3 domain binding; vascular endothelial growth factor receptor binding
Biological Process:  actin filament organization; cell cycle; cell division; cell migration; negative regulation of small GTPase mediated signal transduction; negative regulation of transforming growth factor beta1 production; positive regulation of protein localization to nucleus; proteasomal ubiquitin-dependent protein catabolic process; regulation of actin cytoskeleton reorganization; regulation of receptor-mediated endocytosis; vesicle organization and biogenesis
Reference #:  Q9JLQ0 (UniProtKB)
Alt. Names/Synonyms: AL024079; C78928; CD2-associated protein; Cd2ap; mesenchyme to epithelium transition protein, SH3 domains; Mesenchyme-to-epithelium transition protein with SH3 domains 1; METS-1; Mets1; SH3 domain-containing adapter protein; SH3 domain-containing adaptor protein METS-1
Gene Symbols: Cd2ap
Molecular weight: 70,450 Da
Basal Isoelectric point: 6.07  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CD2AP

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene