CUL5 Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor. Belongs to the cullin family. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 11q22.3
Cellular Component:  Cul5-RING ubiquitin ligase complex; cytosol
Molecular Function:  calcium channel activity; protein binding; signaling receptor activity; ubiquitin protein ligase binding; ubiquitin-protein transferase activity
Biological Process:  calcium ion transmembrane transport; ERBB2 signaling pathway; G1/S transition of mitotic cell cycle; intrinsic apoptotic signaling pathway; post-translational protein modification; protein ubiquitination; viral process
Reference #:  Q93034 (UniProtKB)
Alt. Names/Synonyms: CUL-5; CUL5; cullin 5; Cullin-5; Cullin-5 (vasopressin-activated calcium-mobilizing receptor-1); VACM-1; VACM1; Vasopressin-activated calcium-mobilizing receptor 1; Vasopressin-activated calcium-mobilizing receptor-1
Gene Symbols: CUL5
Molecular weight: 90,955 Da
Basal Isoelectric point: 8.08  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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