RNF26 E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud. Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1. Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING. Also required to limit type I interferon response by promoting autophagic degradation of IRF3. Ubiquitous. Up-regulated in several cancer cell lines. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Ubiquitin conjugating system
Chromosomal Location of human Ortholog: 11q23.3
Cellular Component:  endoplasmic reticulum membrane; integral component of membrane
Molecular Function:  protein binding; ubiquitin protein ligase activity; zinc ion binding
Biological Process:  endosome organization; negative regulation of defense response to virus; protein K11-linked ubiquitination; protein localization to perinuclear region of cytoplasm; protein ubiquitination; regulation of type I interferon production
Reference #:  Q9BY78 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin-protein ligase RNF26; MGC2642; RING finger protein 26; ring finger protein with leucine zipper; RNF26
Gene Symbols: RNF26
Molecular weight: 47,737 Da
Basal Isoelectric point: 8.86  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene