|
EEF1A1
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. Brain, placenta, lung, liver, kidney, pancreas but barely detectable in heart and skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Nucleolus; Translation; Translation elongation |
| Chromosomal Location of human Ortholog: 6q13 |
|
Cellular Component:
cortical actin cytoskeleton; cytoplasm; cytoplasmic side of lysosomal membrane; cytosol; cytosolic ribosome; eukaryotic translation elongation factor 1 complex; extracellular region; ficolin-1-rich granule lumen; nucleolus; nucleus; plasma membrane; ruffle membrane; secretory granule lumen
|
|
Molecular Function:
GTP binding; GTPase activity; kinase binding; molecular adaptor activity; protein binding; protein kinase binding; translation elongation factor activity; tRNA binding
|
|
Biological Process:
cellular response to epidermal growth factor stimulus; positive regulation by host of viral genome replication; regulation of chaperone-mediated autophagy; regulation of D-erythro-sphingosine kinase activity; translation; translational elongation
|
|
Reference #:
P68104
(UniProtKB)
|
|
Alt. Names/Synonyms: CCS-3; CCS3; cervical cancer suppressor 3; CTCL tumor antigen; EE1A1; EEF-1; EEF1A; eEF1A-1; EEF1A1; EF-1-alpha-1; EF-Tu; EF1A; EF1a-like protein; EF1A1; elongation factor 1 alpha subunit; Elongation factor 1-alpha 1; Elongation factor Tu; epididymis secretory sperm binding protein; Eukaryotic elongation factor 1 A-1; eukaryotic translation elongation factor 1 alpha 1; eukaryotic translation elongation factor 1 alpha 1-like 14; FLJ25721; glucocorticoid receptor AF-1 specific elongation factor; GRAF-1EF; HNGC:16303; LENG7; leukocyte receptor cluster (LRC) member 7; Leukocyte receptor cluster member 7; MGC102687; MGC131894; MGC16224; prostate tumor-inducing protein 1; PTI1; translation elongation factor 1 alpha 1-like 14
|
|
Gene Symbols: EEF1A1
|
|
Molecular weight:
50,141 Da
|
|
Basal Isoelectric point:
9.1
Predict pI for various phosphorylation states
|
|
CST Pathways:
Translational Control
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
