PLD1 Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic. Belongs to the phospholipase D family. Expressed abundantly in the pancreas and heart and at high levels in brain, placenta, spleen, uterus and small intestine. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase
Chromosomal Location of Human Ortholog: 2q24
Cellular Component:  apical plasma membrane; cholinergic synapse; endocytic vesicle; endoplasmic reticulum membrane; endosome; Golgi apparatus; Golgi cisterna; Golgi membrane; intracellular membrane-bounded organelle; lamellipodium; late endosome membrane; perinuclear region of cytoplasm; synapse; vesicle
Molecular Function:  N-acylphosphatidylethanolamine-specific phospholipase D activity; phosphatidylinositol binding; phospholipase D activity; protein binding
Biological Process:  cell motility; defense response to Gram-positive bacterium; inositol lipid-mediated signaling; lipid catabolic process; phosphatidic acid biosynthetic process; phospholipid biosynthetic process; phospholipid catabolic process; positive regulation of cell migration; regulation of microvillus assembly; regulation of synaptic vesicle cycle; response to peptide hormone
Reference #:  P70496 (UniProtKB)
Alt. Names/Synonyms: Choline phosphatase 1; Phoshpolipase D gene 1 probably with two splicing variants A and B; Phosphatidylcholine-hydrolyzing phospholipase D1; phospholipase D gene 1, probably with two splicing variants A and B; Phospholipase D1; PLD 1; Pld1; Pld1a; Pld1b; Plda; Pldb; rPLD1
Gene Symbols: Pld1
Molecular weight: 123,814 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PLD1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene