TOP2A iso2 Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation. Belongs to the type II topoisomerase family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 5.99.1.3; Isomerase
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component:  condensed chromosome; DNA topoisomerase complex (ATP-hydrolyzing); nucleolus; nucleoplasm; nucleus; protein-containing complex; ribonucleoprotein complex; viral integration complex
Molecular Function:  ATP binding; chromatin binding; DNA binding; DNA binding, bending; DNA topoisomerase type II (ATP-hydrolyzing) activity; DNA-dependent ATPase activity; drug binding; enzyme binding; histone deacetylase binding; magnesium ion binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein homodimerization activity; protein kinase C binding; ubiquitin binding
Biological Process:  apoptotic chromosome condensation; cellular response to DNA damage stimulus; chromosome segregation; DNA ligation; DNA topological change; embryonic cleavage; female meiotic nuclear division; hematopoietic progenitor cell differentiation; negative regulation of DNA duplex unwinding; positive regulation of apoptotic process; positive regulation of single stranded viral RNA replication via double stranded DNA intermediate; positive regulation of transcription by RNA polymerase II; regulation of circadian rhythm; rhythmic process
Reference #:  P11388-2 (UniProtKB)
Alt. Names/Synonyms: DNA gyrase; DNA topoisomerase (ATP-hydrolyzing); DNA topoisomerase 2-alpha; DNA topoisomerase II alpha; DNA topoisomerase II, 170 kD; DNA topoisomerase II, alpha isozyme; TOP2; TOP2A; TOP2A iso2; topoisomerase (DNA) II alpha 170kDa; TP2A
Gene Symbols: TOP2A
Molecular weight: 177,501 Da
Basal Isoelectric point: 8.85  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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TOP2A iso2

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene