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SPTAN1
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Belongs to the spectrin family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 2 B|2 20.93 cM |
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Cellular Component:
cell junction; cell projection; cortical actin cytoskeleton; cortical cytoskeleton; cuticular plate; cytoplasm; cytoskeleton; cytosol; fascia adherens; glutamatergic synapse; intracellular membrane-bounded organelle; lateral plasma membrane; membrane; microtubule cytoskeleton; paranodal junction; paranode region of axon; plasma membrane; postsynapse; protein-containing complex; Z disc
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Molecular Function:
actin binding; actin filament binding; calcium ion binding; calmodulin binding; metal ion binding; protein binding; protein-containing complex binding; spectrin binding; syntaxin binding
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Biological Process:
actin cytoskeleton organization; actin filament capping
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Reference #:
P16546
(UniProtKB)
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Alt. Names/Synonyms: 2610027H02Rik; alpha-fodrin; Alpha-II spectrin; alpha-spectrin 2, brain; alphaII-spectrin; Fodrin alpha chain; spectrin alpha 2; Spectrin alpha chain, brain; Spectrin alpha chain, non-erythrocytic 1; spectrin alpha, non-erythrocytic 1; Spectrin, non-erythroid alpha chain; Spna-2; Spna2; Spta2; Sptan1; SPTN1
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Gene Symbols: Sptan1
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Molecular weight:
284,597 Da
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Basal Isoelectric point:
5.2
Predict pI for various phosphorylation states
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CST Pathways:
Death Receptor Signaling
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