p16-INK4A
Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cell cycle regulation; Nucleolus; Tumor suppressor |
Chromosomal Location of mouse Ortholog: 4 C4|4 42.15 cM |
Cellular Component:
cytoplasm; granular component; mitochondrion; nuclear body; nucleolus; nucleoplasm; nucleus; protein-containing complex; senescence-associated heterochromatin focus
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Molecular Function:
cyclin-dependent protein serine/threonine kinase inhibitor activity; disordered domain specific binding; DNA binding; MDM2/MDM4 family protein binding; NF-kappaB binding; p53 binding; protein binding; protein kinase binding; RNA polymerase II-specific DNA-binding transcription factor binding; SUMO transferase activity; ubiquitin ligase inhibitor activity; ubiquitin-protein transferase inhibitor activity
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Biological Process:
activation of cysteine-type endopeptidase activity involved in apoptotic process; amyloid fibril formation; apoptotic mitochondrial changes; apoptotic process; apoptotic process involved in mammary gland involution; autophagy of mitochondrion; cell cycle; cellular response to hydrogen peroxide; cellular senescence; epidermis development; glucose homeostasis; keratinocyte differentiation; keratinocyte proliferation; mammary gland epithelial cell proliferation; mitochondrial depolarization; negative regulation of B cell proliferation; negative regulation of cell cycle; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of cell-matrix adhesion; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of DNA-templated transcription; negative regulation of hepatocyte proliferation; negative regulation of immature T cell proliferation in thymus; negative regulation of mammary gland epithelial cell proliferation; negative regulation of NF-kappaB transcription factor activity; negative regulation of phosphorylation; negative regulation of protein binding; negative regulation of protein kinase activity; negative regulation of protein neddylation; negative regulation of proteolysis involved in protein catabolic process; negative regulation of ubiquitin protein ligase activity; negative regulation of ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein transferase activity; nuclear body organization; oncogene-induced cell senescence; positive regulation of apoptotic process; positive regulation of apoptotic process involved in mammary gland involution; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of macrophage apoptotic process; positive regulation of protein localization to nucleus; positive regulation of protein sumoylation; positive regulation of signal transduction by p53 class mediator; positive regulation of smooth muscle cell apoptotic process; positive regulation of transcription by RNA polymerase II; protein destabilization; protein K63-linked ubiquitination; protein localization to nucleolus; protein localization to nucleus; protein polyubiquitination; protein stabilization; regulation of apoptotic DNA fragmentation; regulation of cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of DNA-binding transcription factor activity; regulation of G1/S transition of mitotic cell cycle; regulation of G2/M transition of mitotic cell cycle; regulation of gene expression; regulation of nucleocytoplasmic transport; regulation of protein export from nucleus; regulation of protein stability; regulation of protein targeting to mitochondrion; regulation of ubiquitin protein ligase activity; replicative senescence; response to organic cyclic compound; response to organonitrogen compound; response to xenobiotic stimulus; rRNA processing; rRNA transcription; somatic stem cell division; somatic stem cell population maintenance
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Reference #:
P51480
(UniProtKB)
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Alt. Names/Synonyms: alternative reading frame; Arf; ARF-; ARF-INK4a; CD2A1; CDK4I; Cdkn2a; CDN2A; cyclin dependent kinase inhibitor 2A; Cyclin-dependent kinase 4 inhibitor A; Cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A, isoform 3; Cyclin-dependent kinase inhibitor 2A, isoforms 1/2; cyclin-dependent kinase inhibitor protein; INK4; INK4a-ARF; Ink4a/Arf; mitochondrial smARF; MTS; MTS1; OTTMUSP00000008143; p16; p16(INK4a); p16-INK4; p16-INK4a; p16I; P16ink4a; p19; p19<A; p19<ARF>; p19ARF; Pct; Pctr1
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Gene Symbols: Cdkn2a
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Molecular weight:
17,941 Da
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Basal Isoelectric point:
6.04
Predict pI for various phosphorylation states
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CST Pathways:
G1/S Checkpoint
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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