p16-INK4A Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Nucleolus; Tumor suppressor
Chromosomal Location of Human Ortholog: 4 C4|4 42.15 cM
Cellular Component:  cytoplasm; granular component; mitochondrion; nucleolus; nucleoplasm; nucleus; protein-containing complex; senescence-associated heterochromatin focus
Molecular Function:  cyclin-dependent protein serine/threonine kinase inhibitor activity; disordered domain specific binding; DNA binding; DNA-binding transcription factor activity; MDM2/MDM4 family protein binding; NF-kappaB binding; p53 binding; protein binding; protein kinase binding; protein N-terminus binding; SUMO transferase activity; transcription factor binding; ubiquitin ligase inhibitor activity; ubiquitin-protein transferase inhibitor activity
Biological Process:  activation of cysteine-type endopeptidase activity involved in apoptotic process; aging; amyloid fibril formation; apoptotic mitochondrial changes; apoptotic process; autophagy of mitochondrion; cell aging; cell cycle; cell cycle arrest; cellular response to hydrogen peroxide; cellular senescence; epidermis development; G1/S transition of mitotic cell cycle; glucose homeostasis; mitochondrial depolarization; negative regulation of B cell proliferation; negative regulation of cell cycle; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of cell-matrix adhesion; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of hepatocyte proliferation; negative regulation of immature T cell proliferation in thymus; negative regulation of mammary gland epithelial cell proliferation; negative regulation of NF-kappaB transcription factor activity; negative regulation of phosphorylation; negative regulation of protein binding; negative regulation of protein kinase activity; negative regulation of protein neddylation; negative regulation of proteolysis involved in cellular protein catabolic process; negative regulation of transcription, DNA-templated; negative regulation of ubiquitin protein ligase activity; negative regulation of ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein transferase activity; positive regulation of apoptotic process; positive regulation of apoptotic process involved in mammary gland involution; positive regulation of cell cycle arrest; positive regulation of cellular senescence; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of DNA-binding transcription factor activity; positive regulation of gene expression; positive regulation of macrophage apoptotic process; positive regulation of protein localization to nucleus; positive regulation of protein sumoylation; positive regulation of signal transduction by p53 class mediator; positive regulation of smooth muscle cell apoptotic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein destabilization; protein K63-linked ubiquitination; protein polyubiquitination; protein stabilization; regulation of apoptotic DNA fragmentation; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of G2/M transition of mitotic cell cycle; regulation of gene expression; regulation of nucleocytoplasmic transport; regulation of protein export from nucleus; regulation of protein stability; regulation of protein targeting to mitochondrion; regulation of transcription, DNA-templated; replicative senescence; response to drug; response to organic cyclic compound; response to organonitrogen compound; rRNA processing; rRNA transcription; senescence-associated heterochromatin focus assembly; somatic stem cell division; somatic stem cell population maintenance
Reference #:  P51480 (UniProtKB)
Alt. Names/Synonyms: alternative reading frame; Arf; ARF-; ARF-INK4a; CD2A1; CDK4I; Cdkn2a; CDN2A; cyclin dependent kinase inhibitor 2A; Cyclin-dependent kinase 4 inhibitor A; Cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A, isoform 3; Cyclin-dependent kinase inhibitor 2A, isoforms 1/2; cyclin-dependent kinase inhibitor protein; INK4; INK4a-ARF; Ink4a/Arf; mitochondrial smARF; MTS; MTS1; OTTMUSP00000008143; p16; p16(INK4a); p16-INK4; p16-INK4a; p16I; P16ink4a; p19; p19<A; p19<ARF>; p19ARF; Pct; Pctr1
Gene Symbols: Cdkn2a
Molecular weight: 17,941 Da
Basal Isoelectric point: 6.04  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene