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RITA1
Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis. Belongs to the RITA family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear export |
| Chromosomal Location of human Ortholog: 12q24.13 |
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Cellular Component:
centrosome; cytoplasm; nucleoplasm; nucleus
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Molecular Function:
protein binding; tubulin binding
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Biological Process:
negative regulation of Notch signaling pathway; negative regulation of transcription by RNA polymerase II; neurogenesis; Notch signaling pathway; nuclear export
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Reference #:
Q96K30
(UniProtKB)
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Alt. Names/Synonyms: C12orf52; PSEC0043; RBPJ interacting and tubulin associated 1; RBPJ-interacting and tubulin-associated protein; RBPJ-interacting and tubulin-associated protein 1; RITA; RITA1
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Gene Symbols: RITA1
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Molecular weight:
28,619 Da
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Basal Isoelectric point:
11.07
Predict pI for various phosphorylation states
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