EMILIN1 May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity. Distributed in tissues where resilience and elastic recoil are prominent. Highest levels in the adult small intestine, aorta, lung, uterus, and appendix and in the fetal spleen, kidney, lung, and heart; intermediate expression was detected in adult liver, ovary, colon, stomach, lymph node and spleen; adult heart, bladder, prostate, adrenal gland, mammary gland, placenta and kidney showed low expression whereas a series of other adult tissues, including skeletal muscle and different regions of adult brain show no expression. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Extracellular matrix; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component:  collagen trimer; collagen-containing extracellular matrix; EMILIN complex; extracellular region; extracellular space; integrin alpha4-beta1 complex
Molecular Function:  extracellular matrix constituent conferring elasticity; extracellular matrix structural constituent; identical protein binding; integrin binding involved in cell-matrix adhesion; protein binding
Biological Process:  aortic valve morphogenesis; cell adhesion; cell migration; cell-matrix adhesion; elastic fiber assembly; negative regulation of angiogenesis; negative regulation of cell activation; negative regulation of collagen biosynthetic process; negative regulation of collagen fibril organization; negative regulation of ERK1 and ERK2 cascade; negative regulation of gene expression; negative regulation of macrophage migration; negative regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of extracellular matrix assembly; positive regulation of gene expression; protein homotrimerization
Reference #:  Q9Y6C2 (UniProtKB)
Alt. Names/Synonyms: DKFZp586M121; elastin microfibril interface located protein; Elastin microfibril interface-located protein 1; Elastin microfibril interfacer 1; EMI; EMIL1; EMILIN; EMILIN-1; EMILIN1; gp115
Gene Symbols: EMILIN1
Molecular weight: 106,695 Da
Basal Isoelectric point: 5.1  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene