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PMCA4 iso6
Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. By regulating sperm cell calcium homeostasis, may play a role in sperm motility. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. Isoform XB is the most abundant isoform and is expressed ubiquitously. Isoforms containing segment Z have only been detected in heart, while isoforms containing segment a have been found in heart, stomach and brain cortex. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Channel, calcium; EC 3.6.3.8; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel |
| Chromosomal Location of human Ortholog: 1q32.1 |
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Cellular Component:
basolateral plasma membrane; caveola; glutamatergic synapse; intracellular membrane-bounded organelle; membrane; membrane raft; plasma membrane; presynaptic active zone membrane; protein-containing complex; sperm flagellum; sperm principal piece; T-tubule; Z disc
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Molecular Function:
ATP binding; ATP hydrolysis activity; calcium ion transmembrane transporter activity; calmodulin binding; metal ion binding; nitric-oxide synthase binding; nitric-oxide synthase inhibitor activity; P-type calcium transporter activity; PDZ domain binding; protein binding; protein kinase binding; protein phosphatase 2B binding; scaffold protein binding; sodium channel regulator activity
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Biological Process:
calcium ion export; calcium ion import across plasma membrane; calcium ion transmembrane import into cytosol; calcium ion transmembrane transport; cellular response to acetylcholine; cellular response to epinephrine stimulus; flagellated sperm motility; hippocampus development; intracellular calcium ion homeostasis; monoatomic ion transmembrane transport; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; negative regulation of angiogenesis; negative regulation of arginine catabolic process; negative regulation of blood vessel endothelial cell migration; negative regulation of calcineurin-NFAT signaling cascade; negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of cellular response to vascular endothelial growth factor stimulus; negative regulation of citrulline biosynthetic process; negative regulation of gene expression; negative regulation of nitric oxide biosynthetic process; negative regulation of nitric oxide mediated signal transduction; negative regulation of nitric-oxide synthase activity; negative regulation of peptidyl-cysteine S-nitrosylation; negative regulation of the force of heart contraction; neural retina development; positive regulation of cAMP-dependent protein kinase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein localization to plasma membrane; regulation of cardiac conduction; regulation of cell cycle G1/S phase transition; regulation of cytosolic calcium ion concentration; regulation of sodium ion transmembrane transport; regulation of transcription by RNA polymerase II; response to hydrostatic pressure; spermatogenesis; transport across blood-brain barrier; urinary bladder smooth muscle contraction
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Reference #:
P23634-6
(UniProtKB)
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Alt. Names/Synonyms: AT2B4; ATP2B2; ATP2B4; ATPase plasma membrane Ca2+ transporting 4; ATPase, Ca++ transporting, plasma membrane 4; DKFZp686G08106; DKFZp686M088; Matrix-remodeling-associated protein 1; matrix-remodelling associated 1; MXRA1; plasma membrane calcium ATPase; Plasma membrane calcium ATPase isoform 4; plasma membrane calcium pump; Plasma membrane calcium pump isoform 4; Plasma membrane calcium-transporting ATPase 4; PMCA4; PMCA4 iso6; PMCA4b; PMCA4x; sarcolemmal calcium pump
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Gene Symbols: ATP2B4
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Molecular weight:
133,931 Da
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Basal Isoelectric point:
6.04
Predict pI for various phosphorylation states
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