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FCGR2B iso2
Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell surface; Membrane protein, integral; Oncoprotein |
| Chromosomal Location of mouse Ortholog: 1 H3|1 78.02 cM |
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Cellular Component:
cell body; cell surface; cytoplasm; cytoskeleton; dendritic spine; external side of plasma membrane; extracellular region; Golgi apparatus; membrane; plasma membrane; recycling endosome
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Molecular Function:
amyloid-beta binding; IgG binding; immunoglobulin binding; low-affinity IgG receptor activity; protein binding; protein-containing complex binding; transmembrane signaling receptor activity
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Biological Process:
antigen processing and presentation of exogenous peptide antigen via MHC class II; B cell proliferation; cell surface receptor signaling pathway; cellular response to amyloid-beta; cellular response to molecule of bacterial origin; cerebellum development; defense response; dendrite development; endocytic recycling; establishment of localization in cell; Fc receptor-mediated immune complex endocytosis; immune complex clearance; immunoglobulin mediated immune response; immunoglobulin production; interleukin-10 production; mast cell activation; negative regulation of acute inflammatory response to antigenic stimulus; negative regulation of B cell proliferation; negative regulation of humoral immune response mediated by circulating immunoglobulin; negative regulation of immune response; negative regulation of immunoglobulin production; negative regulation of inflammatory response to antigenic stimulus; negative regulation of interleukin-10 production; negative regulation of neutrophil apoptotic process; negative regulation of phagocytosis; negative regulation of type I hypersensitivity; phagocytosis; phagocytosis, engulfment; positive regulation of DNA-binding transcription factor activity; positive regulation of JNK cascade; positive regulation of phagocytosis; positive regulation of response to endoplasmic reticulum stress; receptor-mediated endocytosis; regulation of dendritic spine maintenance; regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway; regulation of immune response; regulation of long-term neuronal synaptic plasticity; response to bacterium
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Reference #:
P08101-2
(UniProtKB)
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Alt. Names/Synonyms: AI528646; CD32; F630109E10Rik; Fc gamma receptor IIB; Fc gamma RIIB; Fc receptor, IgG, low affinity IIb; Fc-gamma RII; Fc-gamma-RII; Fc-gamma-RIIB; Fc[g]; Fc[g]RII; Fcg; Fcgamm; FcgammaRIIB; Fcgr; Fcgr2; Fcgr2a; Fcgr2b; FCGR2B iso2; FcgRII; Fcr-; Fcr-2; Fcr-3; FcRII; IgG Fc receptor II beta; Low affinity immunoglobulin gamma Fc region receptor II; low affinity immunoglobulin gamma Fc region receptor II-b; Ly-1; Ly-17; Ly-m2; Ly-m20; LyM-; LyM-1; Lymphocyte antigen 17; OTTMUSP00000024374; OTTMUSP00000024375
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Gene Symbols: Fcgr2
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Molecular weight:
31,881 Da
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Basal Isoelectric point:
6.73
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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