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FCGR2B iso2
Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell surface; Membrane protein, integral; Oncoprotein |
| Chromosomal Location of human Ortholog: 1q23.3 |
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Cellular Component:
cell body; dendritic spine; external side of plasma membrane; plasma membrane
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Molecular Function:
amyloid-beta binding; IgG binding; low-affinity IgG receptor activity; protein binding; protein-containing complex binding; transmembrane signaling receptor activity
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Biological Process:
antigen processing and presentation of exogenous peptide antigen via MHC class II; cell surface receptor signaling pathway; cellular response to amyloid-beta; cellular response to molecule of bacterial origin; cerebellum development; defense response; Fc-gamma receptor signaling pathway involved in phagocytosis; follicular B cell differentiation; follicular dendritic cell activation; immune complex clearance by monocytes and macrophages; immune response; immunoglobulin mediated immune response; inflammatory response; mast cell activation; mature B cell differentiation involved in immune response; negative regulation of acute inflammatory response to antigenic stimulus; negative regulation of antibody-dependent cellular cytotoxicity; negative regulation of B cell activation; negative regulation of B cell proliferation; negative regulation of B cell receptor signaling pathway; negative regulation of cytokine production; negative regulation of cytotoxic T cell degranulation; negative regulation of dendritic cell antigen processing and presentation; negative regulation of dendritic cell differentiation; negative regulation of humoral immune response mediated by circulating immunoglobulin; negative regulation of immune response; negative regulation of immunoglobulin production; negative regulation of interleukin-10 production; negative regulation of macrophage activation; negative regulation of neutrophil activation; negative regulation of phagocytosis; negative regulation of type I hypersensitivity; phagocytosis, engulfment; positive regulation of humoral immune response; positive regulation of JNK cascade; positive regulation of phagocytosis; positive regulation of response to endoplasmic reticulum stress; receptor-mediated endocytosis; regulation of adaptive immune response; regulation of B cell antigen processing and presentation; regulation of dendritic spine maintenance; regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway; regulation of immune complex clearance by monocytes and macrophages; regulation of immune response; regulation of innate immune response; regulation of signaling receptor activity; response to bacterium; signal transduction
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Disease: Malaria, Susceptibility To; Systemic Lupus Erythematosus
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Reference #:
P31994-2
(UniProtKB)
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Alt. Names/Synonyms: CD32; CD32B; CDw32; Fc fragment of IgG receptor IIb; Fc fragment of IgG, low affinity II, receptor for (CD32); Fc fragment of IgG, low affinity IIb, receptor (CD32); Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc gamma receptor IIb; Fc gamma RIIb; Fc-gamma RII-b; Fc-gamma RII-c; Fc-gamma-RIIb; Fc-gamma-RIIc; FCG2; FCG2B; FCGR2; FCGR2B; FCGR2B iso2; FCGR2C; FcRII-b; FcRII-c; IGFR2; IgG Fc receptor II-b; IgG Fc receptor II-c; Low affinity immunoglobulin gamma Fc region receptor II-b; Low affinity immunoglobulin gamma Fc region receptor II-c
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Gene Symbols: FCGR2B
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Molecular weight:
31,944 Da
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Basal Isoelectric point:
5.97
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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