|
caveolin-1
May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation. Belongs to the caveolin family. Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Expressed in the brain. 2 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator |
| Chromosomal Location of rat Ortholog: 4q21 |
|
Cellular Component:
acrosomal membrane; apical plasma membrane; basal plasma membrane; basolateral plasma membrane; caveola; caveolar macromolecular signaling complex; cell cortex; cell surface; cilium; cytoplasmic vesicle; endoplasmic reticulum; endosome; exocytic vesicle; focal adhesion; Golgi apparatus; Golgi membrane; lipid droplet; membrane; membrane raft; perinuclear region of cytoplasm; peroxisomal membrane; plasma membrane; protein-containing complex; sarcolemma
|
|
Molecular Function:
ATPase binding; enzyme binding; identical protein binding; inward rectifier potassium channel inhibitor activity; kinase binding; molecular adaptor activity; nitric-oxide synthase binding; peptidase activator activity; protein binding; protein heterodimerization activity; protein kinase binding; protein-containing complex binding; protein-macromolecule adaptor activity; receptor serine/threonine kinase binding; signaling receptor binding; small GTPase binding; SNARE binding; syntaxin binding; transmembrane transporter binding
|
|
Biological Process:
angiogenesis; angiotensin-activated signaling pathway involved in heart process; animal organ regeneration; apoptotic signaling pathway; basement membrane organization; calcium ion homeostasis; calcium ion transport; caveola assembly; caveolin-mediated endocytosis; cell differentiation; cell population proliferation; cellular response to exogenous dsRNA; cellular response to hyperoxia; cellular response to hypoxia; cellular response to mechanical stimulus; cellular response to peptide hormone stimulus; cellular response to starvation; cellular response to transforming growth factor beta stimulus; cellular senescence; cholesterol efflux; cholesterol homeostasis; cytokine-mediated signaling pathway; endothelial cell proliferation; establishment of localization in cell; fibroblast proliferation; glandular epithelial cell differentiation; insulin receptor internalization; intracellular calcium ion homeostasis; intracellular nitric oxide homeostasis; lactation; lipid storage; maintenance of protein location in cell; mammary gland development; mammary gland involution; MAPK cascade; membrane depolarization; microtubule polymerization; muscle cell cellular homeostasis; negative regulation of anoikis; negative regulation of BMP signaling pathway; negative regulation of calcium ion import across plasma membrane; negative regulation of canonical Wnt signaling pathway; negative regulation of cation channel activity; negative regulation of cell population proliferation; negative regulation of cytokine-mediated signaling pathway; negative regulation of endothelial cell proliferation; negative regulation of epithelial cell differentiation; negative regulation of ERK1 and ERK2 cascade; negative regulation of fibroblast proliferation; negative regulation of inward rectifier potassium channel activity; negative regulation of MAP kinase activity; negative regulation of MAPK cascade; negative regulation of muscle cell apoptotic process; negative regulation of necroptotic process; negative regulation of neuron differentiation; negative regulation of nitric oxide biosynthetic process; negative regulation of nitric-oxide synthase activity; negative regulation of peptidyl-serine phosphorylation; negative regulation of peptidyl-tyrosine autophosphorylation; negative regulation of pinocytosis; negative regulation of potassium ion transmembrane transport; negative regulation of protein binding; negative regulation of protein tyrosine kinase activity; negative regulation of protein ubiquitination; negative regulation of receptor signaling pathway via JAK-STAT; negative regulation of signal transduction; negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of tyrosine phosphorylation of STAT protein; negative regulation of vascular associated smooth muscle cell proliferation; nitric oxide biosynthetic process; positive regulation of calcium ion transport into cytosol; positive regulation of canonical Wnt signaling pathway; positive regulation of catalytic activity; positive regulation of cell adhesion molecule production; positive regulation of cell migration; positive regulation of cholesterol efflux; positive regulation of cold-induced thermogenesis; positive regulation of endocytosis; positive regulation of endothelial cell proliferation; positive regulation of ER-associated ubiquitin-dependent protein catabolic process; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of gap junction assembly; positive regulation of gene expression; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of microtubule polymerization; positive regulation of NF-kappaB transcription factor activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein binding; positive regulation of protein ubiquitination; positive regulation of signal transduction; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of vasoconstriction; post-transcriptional regulation of gene expression; protein localization; protein localization to basolateral plasma membrane; protein localization to plasma membrane raft; protein transport; receptor internalization; receptor internalization involved in canonical Wnt signaling pathway; receptor-mediated endocytosis of virus by host cell; regulation of blood coagulation; regulation of cell communication by electrical coupling involved in cardiac conduction; regulation of cytosolic calcium ion concentration; regulation of entry of bacterium into host cell; regulation of fatty acid metabolic process; regulation of heart rate by cardiac conduction; regulation of membrane repolarization during action potential; regulation of peptidase activity; regulation of ruffle assembly; regulation of smooth muscle contraction; regulation of the force of heart contraction; regulation of the force of heart contraction by chemical signal; regulation of ventricular cardiac muscle cell action potential; response to bacterium; response to calcium ion; response to estrogen; response to gamma radiation; response to glucocorticoid; response to hypoxia; response to ischemia; response to mechanical stimulus; response to nutrient; response to progesterone; response to xenobiotic stimulus; skeletal muscle tissue development; T cell costimulation; triglyceride metabolic process; tyrosine phosphorylation of STAT protein; vasculogenesis; vasoconstriction; vesicle organization
|
|
Reference #:
P41350
(UniProtKB)
|
|
Alt. Names/Synonyms: Cav; Cav1; caveolin 1, caveolae protein; caveolin caveolae protein 22 kDa; caveolin, caveolae protein 1; Caveolin-1; MGC187299
|
|
Gene Symbols: Cav1
|
|
Molecular weight:
20,553 Da
|
|
Basal Isoelectric point:
5.3
Predict pI for various phosphorylation states
|
|
CST Pathways:
Adherens Junction Dynamics
|
ErbB/HER Signaling
|
Insulin Receptor Signaling
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
