TRPM5 Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM5 sub-subfamily. Strongly expressed in fetal brain, liver and kidney, and in adult prostate, testis, ovary, colon and peripheral blood leukocytes. Also expressed in a large proportion of Wilms' tumors and rhabdomyosarcomas. In monochromosomal cell lines shows exclusive paternal expression. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component:  dendrite; integral component of membrane; neuronal cell body; plasma membrane
Molecular Function:  calcium activated cation channel activity; ion channel activity; potassium channel activity; sodium channel activity; voltage-gated ion channel activity
Biological Process:  calcium ion transmembrane transport; potassium ion transmembrane transport; regulation of ion transmembrane transport; sensory perception of taste; sodium ion transmembrane transport
Reference #:  Q9NZQ8 (UniProtKB)
Alt. Names/Synonyms: Long transient receptor potential channel 5; LTrpC-5; LTRPC5; MLSN1 and TRP-related; MLSN1- and TRP-related gene 1 protein; MTR1; Transient receptor potential cation channel subfamily M member 5; transient receptor potential cation channel, subfamily M, member 5; TRPM5
Gene Symbols: TRPM5
Molecular weight: 131,451 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
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TRPM5

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB