TRIP6 Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. Belongs to the zyxin/ajuba family. Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component:  cytoskeleton; cytosol; focal adhesion; nucleus; plasma membrane
Molecular Function:  interleukin-1 receptor binding; kinase binding; metal ion binding; protein binding; thyroid hormone receptor binding
Biological Process:  focal adhesion assembly; positive regulation of cell migration; positive regulation of NIK/NF-kappaB signaling
Reference #:  Q15654 (UniProtKB)
Alt. Names/Synonyms: MGC10556; MGC10558; MGC29959; MGC3837; MGC4423; OIP-1; OIP1; Opa-interacting protein 1; thyroid hormone receptor interactor 6; Thyroid receptor-interacting protein 6; TR-interacting protein 6; TRIP-6; TRIP6; ZRP-1; zyxin related protein 1; Zyxin-related protein 1
Gene Symbols: TRIP6
Molecular weight: 50,288 Da
Basal Isoelectric point: 7.19  Predict pI for various phosphorylation states
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TRIP6

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA