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TRIP6
Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. Belongs to the zyxin/ajuba family. Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator |
| Chromosomal Location of human Ortholog: 7q22.1 |
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Cellular Component:
cytoplasm; cytoskeleton; cytosol; focal adhesion; nucleus; plasma membrane; stress fiber
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Molecular Function:
interleukin-1 receptor binding; kinase binding; metal ion binding; nuclear thyroid hormone receptor binding; protein binding
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Biological Process:
chordate embryonic development; focal adhesion assembly; positive regulation of cell migration; positive regulation of NIK/NF-kappaB signaling; signal transduction
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Reference #:
Q15654
(UniProtKB)
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Alt. Names/Synonyms: MGC10556; MGC10558; MGC29959; MGC3837; MGC4423; OIP-1; OIP1; Opa-interacting protein 1; thyroid hormone receptor interacting protein 6; thyroid hormone receptor interactor 6; Thyroid receptor-interacting protein 6; TR-interacting protein 6; TRIP-6; TRIP6; TRIP6i2; ZRP-1; zyxin related protein 1; Zyxin-related protein 1
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Gene Symbols: TRIP6
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Molecular weight:
50,288 Da
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Basal Isoelectric point:
7.19
Predict pI for various phosphorylation states
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