ZNF598 E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation. Required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40S ribosomal protein RPS10/eS10, RPS20/uS10 and RPS3/uS3. Stalling precludes synthesis of a long poly-lysine tail and initiates the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide. Also acts as a component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. Belongs to the ZNF598 family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: 
Molecular Function:  metal ion binding; protein binding; ribosome binding; ubiquitin protein ligase activity
Biological Process:  protein monoubiquitination; protein ubiquitination; rescue of stalled ribosome
Reference #:  Q86UK7 (UniProtKB)
Alt. Names/Synonyms: DKFZp762F135; E3 ubiquitin-protein ligase ZNF598; FLJ00086; Zinc finger protein 598; ZN598; ZNF598
Gene Symbols: ZNF598
Molecular weight: 98,637 Da
Basal Isoelectric point: 8.75  Predict pI for various phosphorylation states
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ZNF598

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB