WHSC1 Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform 2 may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - lysine degradation; EC; Methyltransferase; Methyltransferase, protein lysine; Oncoprotein; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component:  cytoplasm; nucleoplasm; nucleus
Molecular Function:  chromatin binding; DNA-binding transcription factor activity, RNA polymerase II-specific; histone methyltransferase activity (H4-K20 specific); metal ion binding; protein binding; sequence-specific DNA binding
Biological Process:  atrial septum primum morphogenesis; atrial septum secundum morphogenesis; bone development; double-strand break repair via nonhomologous end joining; histone H3-K36 methylation; histone H4-K20 methylation; membranous septum morphogenesis; negative regulation of transcription by RNA polymerase II; positive regulation of isotype switching to IgA isotypes; regulation of double-strand break repair via nonhomologous end joining; regulation of establishment of protein localization
Disease: Wolf-hirschhorn Syndrome
Reference #:  O96028 (UniProtKB)
Alt. Names/Synonyms: FLJ23286; Histone-lysine N-methyltransferase NSD2; IL5 promoter REII region-binding protein; KIAA1090; MGC176638; MMSET; multiple myeloma SET domain containing protein type III; Multiple myeloma SET domain-containing protein; NSD2; nuclear receptor binding SET domain protein 2; Nuclear SET domain-containing protein 2; Probable histone-lysine N-methyltransferase NSD2; Protein trithorax-5; REIIBP; trithorax/ash1-related protein 5; TRX5; WHS; WHSC1; Wolf-Hirschhorn syndrome candidate 1; Wolf-Hirschhorn syndrome candidate 1 protein
Gene Symbols: NSD2
Molecular weight: 152,258 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein