Abi-1 May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. Belongs to the ABI family. Widely expressed, with highest expression in brain. 12 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 10p12.1
Cellular Component:  cytoskeleton; cytosol; endoplasmic reticulum; filopodium tip; growth cone; intracellular anatomical structure; lamellipodium; nucleus; postsynaptic density; SCAR complex
Molecular Function:  cytoskeletal protein binding; protein binding; protein tyrosine kinase activator activity; SH3 domain binding; signaling adaptor activity
Biological Process:  actin polymerization or depolymerization; dendrite morphogenesis; lamellipodium morphogenesis; megakaryocyte development; negative regulation of cell population proliferation; positive regulation of protein tyrosine kinase activity; somitogenesis; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q8IZP0 (UniProtKB)
Alt. Names/Synonyms: Abelson interactor 1; Abi-1; ABI1; Abl interactor 1; Abl-binding protein 4; abl-interactor 1; Abl-interactor protein 1 long; AblBP4; e3B1; eps8 binding protein; Eps8 SH3 domain-binding protein; Eps8-binding protein; interactor protein AblBP4; nap1 binding protein; Nap1-binding protein; Nap1BP; spectrin SH3 domain binding protein 1; Spectrin SH3 domain-binding protein 1; SSH3BP; SSH3BP1
Gene Symbols: ABI1
Molecular weight: 55,081 Da
Basal Isoelectric point: 6.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene