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PZR
Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. Belongs to the myelin P0 protein family. Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hematopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appears to be the major isoform in CD34- promyelocytic and promonocytic cells. During differentiation in monocytic cells, the expression level of isoform 3 decreases and that of isoform 1 increases. Isoform 1 is prominent in stromal cells and, to a lesser extent, in umbilical vein endothelial cells and erythroid progenitors. Isoform 2 is expressed in a erythroid progenitor cell line. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Membrane protein, integral |
| Chromosomal Location of Human Ortholog: 1q24.2 |
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Cellular Component:
integral component of plasma membrane
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Molecular Function:
protein binding; structural molecule activity
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Biological Process:
cell-cell signaling; transmembrane receptor protein tyrosine kinase signaling pathway
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Reference #:
O95297
(UniProtKB)
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Alt. Names/Synonyms: FLJ21047; immunoglobulin family transmembrane protein; MPZL1; MPZL1b; myelin protein zero-like 1; Myelin protein zero-like protein 1; protein zero related; Protein zero-related; PZR; PZR1b; PZRa; PZRb
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Gene Symbols: MPZL1
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Molecular weight:
29,082 Da
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Basal Isoelectric point:
8.85
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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