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PZR
an immunoglobulin superfamily cell surface protein. Contains two tyrosine-based inhibition motifs (ITIMs) responsible for binding of SHP-2. When phosphorylated, it can specifically bind SHP-2, blocking its translocation, and interupting its function. Treatment of several cell lines with ConA caused tyrosine phosphorylation of PZR. Two alternatively spliced isoforms have been reported. One isoform, PZR1b, lacks the ITIMs and has a dominant negative effect upon full-length PZR and its recruitment of SHP-2. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Membrane protein, integral |
| Chromosomal Location of Human Ortholog: 1q24.2 |
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Cellular Component:
integral component of plasma membrane
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Molecular Function:
protein binding; structural molecule activity
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Biological Process:
cell-cell signaling; transmembrane receptor protein tyrosine kinase signaling pathway
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Reference #:
O95297
(UniProtKB)
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Alt. Names/Synonyms: FLJ21047; immunoglobulin family transmembrane protein; MPZL1; MPZL1b; myelin protein zero-like 1; Myelin protein zero-like protein 1; protein zero related; Protein zero-related; PZR; PZR1b; PZRa; PZRb
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Gene Symbols: MPZL1
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Molecular weight:
29,082 Da
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Basal Isoelectric point:
8.85
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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