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ZO2
Plays a role in tight junctions and adherens junctions. Belongs to the MAGUK family. This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues. 7 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 9q21.11 |
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Cellular Component:
adherens junction; bicellular tight junction; cell-cell contact zone; cytosol; nucleoplasm; nucleus; plasma membrane
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Molecular Function:
cell adhesion molecule binding; guanylate kinase activity; protein binding; protein domain specific binding; protein tyrosine kinase binding; protein-macromolecule adaptor activity; transmembrane transporter binding
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Biological Process:
cell-cell adhesion; cell-cell junction organization; establishment of endothelial intestinal barrier; GDP metabolic process; GMP metabolic process; homotypic cell-cell adhesion; intestinal absorption; maintenance of blood-brain barrier; positive regulation of blood-brain barrier permeability; protein localization to cell-cell junction; regulation of membrane permeability; response to organic substance
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Disease: Cholestasis, Progressive Familial Intrahepatic, 4; Hypercholanemia, Familial
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Reference #:
Q9UDY2
(UniProtKB)
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Alt. Names/Synonyms: C9DUPq21.11; DFNA51; DUP9q21.11; Friedreich ataxia region gene X104 (tight junction protein ZO-2); MGC26306; PFIC4; Tight junction protein 2; tight junction protein 2 (zona occludens 2); tight junction protein ZO 2; Tight junction protein ZO-2; TJP2; X104; ZO2; zona occludens 2; Zona occludens protein 2; Zonula occludens protein 2
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Gene Symbols: TJP2
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Molecular weight:
133,958 Da
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Basal Isoelectric point:
6.96
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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