ZO2 Plays a role in tight junctions and adherens junctions. Belongs to the MAGUK family. This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues. 7 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q21.11
Cellular Component:  adherens junction; bicellular tight junction; cell junction; cytosol; nucleoplasm; plasma membrane
Molecular Function:  guanylate kinase activity; protein binding; protein binding, bridging; protein domain specific binding
Biological Process:  establishment of endothelial intestinal barrier; GDP metabolic process; GMP metabolic process; hippo signaling; intestinal absorption; regulation of membrane permeability
Disease: Cholestasis, Progressive Familial Intrahepatic, 4; Hypercholanemia, Familial
Reference #:  Q9UDY2 (UniProtKB)
Alt. Names/Synonyms: Friedreich ataxia region gene X104 (tight junction protein ZO-2); MGC26306; Tight junction protein 2; tight junction protein 2 (zona occludens 2); tight junction protein ZO 2; Tight junction protein ZO-2; TJP2; X104; ZO2; Zona occludens protein 2; Zonula occludens protein 2
Gene Symbols: TJP2
Molecular weight: 133,958 Da
Basal Isoelectric point: 6.96  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein