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SAMSN1
Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation. Detected in peripheral blood B-cells (at protein level). Detected in spleen, liver and peripheral blood. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of human Ortholog: 21q11.2 |
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Cellular Component:
cytoplasm; cytosol; nucleus; ruffle
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Molecular Function:
phosphotyrosine residue binding
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Biological Process:
negative regulation of adaptive immune response; negative regulation of B cell activation; negative regulation of peptidyl-tyrosine phosphorylation
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Reference #:
Q9NSI8
(UniProtKB)
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Alt. Names/Synonyms: HACS1; hematopoietic adapter-containing SH3 and sterile alpha-motif (SAM) domains 1; hematopoietic adapter-containing SH3 and sterile I+/--motif (SAM) domains 1; Hematopoietic adaptor containing SH3 and SAM domains 1; NASH1; nuclear localization signals, SAM and SH3 domain containing 1; SAM and SH3 domain containing 2; SAM domain, SH3 domain and nuclear localisation signals, 1; SAM domain, SH3 domain and nuclear localization signals 1; SAM domain, SH3 domain and nuclear localization signals protein 1; SAM domain-containing protein SAMSN-1; SAMN1; SAMSN1; SASH2; SH3-SAM adaptor protein; SH3D6B; SLy2; Src homology domain 3 (SH3)-containing adapter protein SH3 lymphocyte protein 2
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Gene Symbols: SAMSN1
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Molecular weight:
41,708 Da
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Basal Isoelectric point:
5.28
Predict pI for various phosphorylation states
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