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plakophilin 3
May play a role in junctional plaques. Belongs to the beta-catenin family. Isoform PKP3a is found in desmosomes of most simple and stratified epithelia. Not found in foreskin fibroblasts and various sarcoma-derived cell lines. Beside dendritic reticular cells of lymphatic follicles not found in non-epithelial desmosome-bearing tissues. Isoform PKP3b is abundant in the desmosomes of stratified epithelial cell but absent in simple epithelial cells, it is also expressed in the colon and its tumors. 2 human isoforms generated by alternative promoter usage have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion |
| Chromosomal Location of human Ortholog: 11p15.5 |
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Cellular Component:
adherens junction; cell junction; cell-cell junction; cornified envelope; cytoplasm; desmosome; messenger ribonucleoprotein complex; nucleoplasm; nucleus; plasma membrane
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Molecular Function:
alpha-catenin binding; cadherin binding; cell adhesion molecule binding; enzyme binding; protein binding; RNA binding; translation regulator activity
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Biological Process:
cell-cell adhesion; cell-cell junction assembly; desmosome assembly; negative regulation of mRNA catabolic process; positive regulation of gene expression; protein localization to plasma membrane; regulation of translation
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Reference #:
Q9Y446
(UniProtKB)
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Alt. Names/Synonyms: PKP3; plakophilin 3; plakophilin 3b; Plakophilin-3
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Gene Symbols: PKP3
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Molecular weight:
87,082 Da
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Basal Isoelectric point:
9.39
Predict pI for various phosphorylation states
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