MAP1B Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. Belongs to the MAP1 family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 5q13.2
Cellular Component:  apical dendrite; axon; basal dendrite; cell junction; cytosol; dendrite; dendritic spine; growth cone; hippocampal mossy fiber; microtubule; neuronal cell body; perikaryon; perinuclear region of cytoplasm; photoreceptor outer segment; plasma membrane; postsynaptic density; somatodendritic compartment; varicosity
Molecular Function:  microtubule binding; phospholipid binding; protein binding; protein-containing complex binding; structural molecule activity
Biological Process:  axon extension; cellular process; cellular response to growth factor stimulus; cellular response to peptide hormone stimulus; developmental maturation; establishment of monopolar cell polarity; induction of synaptic plasticity by chemical substance; microtubule bundle formation; mitochondrion transport along microtubule; negative regulation of intracellular transport; negative regulation of microtubule depolymerization; neuron migration; peripheral nervous system axon regeneration; positive regulation of axon extension; positive regulation of microtubule polymerization; response to carbohydrate; response to drug; response to estradiol; response to inorganic substance; response to insecticide; response to mechanical stimulus; response to vitamin A; synapse assembly
Reference #:  P46821 (UniProtKB)
Alt. Names/Synonyms: DKFZp686E1099; DKFZp686F1345; FLJ38954; FUTSCH; MAP-1B; MAP1 light chain LC1; MAP1B; MAP5; Microtubule-associated protein 1B
Gene Symbols: MAP1B
Molecular weight: 270,634 Da
Basal Isoelectric point: 4.73  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Select Structure to View Below

MAP1B

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein