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UBR5
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of Human Ortholog: 8q22.3 |
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Cellular Component:
cytosol; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein-containing complex
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Molecular Function:
protein binding; RNA binding; ubiquitin binding; ubiquitin protein ligase activity; ubiquitin-ubiquitin ligase activity; zinc ion binding
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Biological Process:
cellular response to DNA damage stimulus; DNA repair; negative regulation of double-strand break repair; negative regulation of histone H2A K63-linked ubiquitination; positive regulation of canonical Wnt signaling pathway; positive regulation of gene expression; positive regulation of protein import into nucleus; progesterone receptor signaling pathway; protein K48-linked ubiquitination; protein polyubiquitination; viral process
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Reference #:
O95071
(UniProtKB)
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Alt. Names/Synonyms: DD5; E3 identified by differential display; E3 ubiquitin protein ligase, HECT domain containing, 1; E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase, HECT domain-containing 1; EDD; EDD1; FLJ11310; hHYD; HYD; Hyperplastic discs protein homolog; KIAA0896; MGC57263; progestin induced protein; Progestin-induced protein; ubiquitin protein ligase E3 component n-recognin 5; ubiquitin-protein ligase; UBR5
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Gene Symbols: UBR5
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Molecular weight:
309,352 Da
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Basal Isoelectric point:
5.59
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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