CTNND1 Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway. Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage. Belongs to the beta-catenin family. Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs. 32 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11q12.1
Cellular Component:  catenin complex; cell-cell junction; cytoplasm; cytosol; dendritic spine; glutamatergic synapse; growth cone; hippocampal mossy fiber to CA3 synapse; lamellipodium; midbody; nucleus; plasma membrane; postsynaptic density, intracellular component; presynaptic active zone cytoplasmic component; Schaffer collateral - CA1 synapse; zonula adherens
Molecular Function:  cadherin binding; protein binding; protein kinase binding; signaling receptor binding
Biological Process:  adherens junction organization; brain development; cell adhesion; entry of bacterium into host cell; negative regulation of canonical Wnt signaling pathway; regulation of postsynaptic membrane neurotransmitter receptor levels; Wnt signaling pathway
Disease: Blepharocheilodontic Syndrome 2
Reference #:  O60716 (UniProtKB)
Alt. Names/Synonyms: BCDS2; Cadherin-associated Src substrate; CAS; catenin (cadherin-associated protein), delta 1; catenin delta 1; Catenin delta-1; CTND1; CTNND; CTNND1; KIAA0384; p120; p120 catenin; p120(cas); p120(ctn); P120CAS; P120CTN
Gene Symbols: CTNND1
Molecular weight: 108,170 Da
Basal Isoelectric point: 5.86  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein