HEFL Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. Belongs to the CAS family. Expressed abundantly in lung and spleen. Also highly expressed in ovarian and leukemia cell lines. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of human Ortholog: 20q13.31
Cellular Component:  cytoplasm; cytoskeleton; focal adhesion; plasma membrane
Molecular Function:  protein tyrosine kinase binding
Biological Process:  actin filament reorganization; cell adhesion; cell migration; positive regulation of cell migration; positive regulation of protein kinase B signaling; positive regulation of protein tyrosine kinase activity; positive regulation of substrate adhesion-dependent cell spreading; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q9NQ75 (UniProtKB)
Alt. Names/Synonyms: C20orf32; Cas scaffold protein family member 4; Cas scaffolding protein family member 4; CAS4; CASS4; HEF-like protein; HEF1-EFS-p130Cas-like protein; HEFL; HEPL
Gene Symbols: CASS4
Molecular weight: 87,144 Da
Basal Isoelectric point: 6.66  Predict pI for various phosphorylation states
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HEFL

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein