ANXA2 a calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. Heterotetramer containing 2 light chains of S100A10 2 heavy chains of ANXA2. May cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 15q22.2
Cellular Component:  azurophil granule lumen; basement membrane; basolateral plasma membrane; cell cortex; cell surface; cytoplasm; cytosol; early endosome; endosome; extracellular exosome; extracellular region; extrinsic component of plasma membrane; late endosome membrane; lipid droplet; lysosomal membrane; macropinosome; melanosome; midbody; myelin sheath adaxonal region; PCSK9-AnxA2 complex; perinuclear region of cytoplasm; plasma membrane; ruffle; sarcolemma; Schmidt-Lanterman incisure
Molecular Function:  calcium ion binding; calcium-dependent phospholipid binding; calcium-dependent protein binding; cytoskeletal protein binding; identical protein binding; molecular function regulator; phosphatidylinositol-4,5-bisphosphate binding; phospholipase A2 inhibitor activity; protease binding; protein binding; S100 protein binding
Biological Process:  angiogenesis; body fluid secretion; calcium ion transmembrane transport; catabolism by host of symbiont protein; cell-cell adhesion; interleukin-12-mediated signaling pathway; membrane raft assembly; negative regulation by host of symbiont molecular function; negative regulation of catalytic activity; negative regulation of development of symbiont involved in interaction with host; negative regulation of low-density lipoprotein particle receptor catabolic process; neutrophil degranulation; osteoclast development; positive regulation of low-density lipoprotein particle clearance; positive regulation of low-density lipoprotein particle receptor binding; positive regulation of low-density lipoprotein receptor activity; positive regulation of receptor recycling; positive regulation of receptor-mediated endocytosis involved in cholesterol transport; positive regulation of vacuole organization; positive regulation of vesicle fusion; protein heterotetramerization; regulation of cytosolic calcium ion concentration; response to thyroid hormone; vesicle budding from membrane
Reference #:  P07355 (UniProtKB)
Alt. Names/Synonyms: Annexin A2; Annexin II; Annexin-2; ANX2; ANX2L4; anxa 2; ANXA2; CAL1H; Calpactin I heavy chain; calpactin I heavy polypeptide; Calpactin-1 heavy chain; chromobindin 8; Chromobindin-8; LIP2; Lipocortin II; LPC2; LPC2D; p36; PAP-IV; Placental anticoagulant protein IV; Protein I
Gene Symbols: ANXA2
Molecular weight: 38,604 Da
Basal Isoelectric point: 7.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein