ADD1 Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. Belongs to the aldolase class II family. Adducin subfamily. Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 5 B2|5 17.9 cM
Cellular Component:  cell-cell adherens junction; cytoplasm; cytoskeleton; dendrite; dendritic spine; F-actin capping protein complex; membrane; nuclear body; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; plasma membrane raft; postsynaptic density; synapse
Molecular Function:  actin binding; actin filament binding; calmodulin binding; protein heterodimerization activity; protein homodimerization activity; spectrin binding; structural molecule activity; T cell receptor binding; transcription factor binding
Biological Process:  actin filament bundle assembly; barbed-end actin filament capping; cell morphogenesis; cell volume homeostasis; cellular response to calcium ion; cellular response to retinoic acid; erythrocyte differentiation; hemoglobin metabolic process; homeostasis of number of cells within a tissue; in utero embryonic development; multicellular organism growth; negative regulation of actin filament polymerization; positive regulation of adherens junction organization; positive regulation of angiogenesis; positive regulation of endocytosis; positive regulation of establishment of endothelial barrier; positive regulation of protein binding
Reference #:  Q9QYC0 (UniProtKB)
Alt. Names/Synonyms: Add1; ADDA; adducin 1 (alpha); AI256389; Alpha-adducin; Erythrocyte adducin subunit alpha; OTTMUSP00000026751; OTTMUSP00000026789
Gene Symbols: Add1
Molecular weight: 80,647 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene