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ADD1
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. Belongs to the aldolase class II family. Adducin subfamily. Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 4p16.3 |
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Cellular Component:
adherens junction; cytoplasm; cytoskeleton; cytosol; F-actin capping protein complex; nuclear body; nucleoplasm; nucleus; plasma membrane; postsynaptic density
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Molecular Function:
actin binding; actin filament binding; calmodulin binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II-specific DNA-binding transcription factor binding; spectrin binding
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Biological Process:
actin cytoskeleton organization; actin filament bundle assembly; barbed-end actin filament capping; cellular response to calcium ion; positive regulation of adherens junction organization; positive regulation of establishment of endothelial barrier; positive regulation of protein binding
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Disease: Hypertension, Essential
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Reference #:
P35611
(UniProtKB)
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Alt. Names/Synonyms: ADD1; ADDA; adducin 1; adducin 1 (alpha); Alpha-adducin; erythrocyte adducin alpha subunit; Erythrocyte adducin subunit alpha; MGC3339; MGC44427
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Gene Symbols: ADD1
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Molecular weight:
80,955 Da
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Basal Isoelectric point:
5.6
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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