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RAB18
Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration. Belongs to the small GTPase superfamily. Rab family. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab |
| Chromosomal Location of mouse Ortholog: 18 A1|18 4.53 cM |
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Cellular Component:
endomembrane system; endoplasmic reticulum; endoplasmic reticulum tubular network; Golgi apparatus; lipid droplet; membrane; plasma membrane; synapse
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Molecular Function:
GDP binding; GTP binding; GTPase activity; nucleotide binding
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Biological Process:
endoplasmic reticulum tubular network organization; import into nucleus; intracellular protein transport; lipid droplet organization; multicellular organism development; protein transport
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Reference #:
P35293
(UniProtKB)
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Alt. Names/Synonyms: AA959686; GTP-binding protein Rab18; Rab18; RAB18, member RAS oncogene family; Ras-related protein Rab-18
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Gene Symbols: Rab18
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Molecular weight:
23,035 Da
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Basal Isoelectric point:
5.24
Predict pI for various phosphorylation states
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