RAB18 Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration. Belongs to the small GTPase superfamily. Rab family. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab
Chromosomal Location of Human Ortholog: 18 A1|18 4.53 cM
Cellular Component:  endoplasmic reticulum tubular network; Golgi apparatus; membrane; plasma membrane; synapse
Molecular Function:  GDP binding; GTP binding; GTPase activity; nucleotide binding
Biological Process:  endoplasmic reticulum tubular network organization; import into nucleus; intracellular protein transport; lipid droplet organization; multicellular organism development; protein transport; Rab protein signal transduction
Reference #:  P35293 (UniProtKB)
Alt. Names/Synonyms: AA959686; GTP-binding protein Rab18; Rab18; RAB18, member RAS oncogene family; Ras-related protein Rab-18
Gene Symbols: Rab18
Molecular weight: 23,035 Da
Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene