|
NEDD8
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. Belongs to the ubiquitin family. Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes. Note: This description may include information from UniProtKB.
|
| Protein type: Ubiquitin-like modifier |
| Chromosomal Location of mouse Ortholog: 14 C3|14 28.19 cM |
|
Cellular Component:
cytoplasm; cytosol; nucleoplasm; nucleus
|
|
Molecular Function:
protein binding; protein tag activity; ubiquitin protein ligase binding
|
|
Biological Process:
modification-dependent protein catabolic process; protein localization; protein neddylation; protein ubiquitination; regulation of proteolysis; regulation of transcription by RNA polymerase II; response to organic cyclic compound
|
|
Reference #:
P29595
(UniProtKB)
|
|
Alt. Names/Synonyms: NEDD-8; NEDD8; Neddylin; Neural precursor cell expressed developmentally down-regulated protein 8; neural precursor cell expressed, developmentally down-regulated gene 8; Rub; Rub1; Ubiquitin-like protein Nedd8
|
|
Gene Symbols: Nedd8
|
|
Molecular weight:
8,972 Da
|
|
Basal Isoelectric point:
6.58
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
