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SLAP-130
Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of mouse Ortholog: 15|15 A1 |
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Cellular Component:
anchoring junction; cytoplasm; cytosol; nucleus; plasma membrane; protein-containing complex
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Molecular Function:
lipid binding; protein binding; protein-containing complex binding
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Biological Process:
integrin-mediated signaling pathway; mast cell activation; protein localization to plasma membrane; T cell receptor signaling pathway
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Reference #:
O35601
(UniProtKB)
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Alt. Names/Synonyms: ADAP; Adhesion and degranulation promoting adaptor protein; B630013F22Rik; Fyb; FYB-120/130; FYB1; FYN binding protein; FYN binding protein FYB-130; FYN-binding protein; FYN-binding protein 1; FYN-T-binding protein; p120/130; p120/p130; SLAP-130; SLAP130; SLP-76-associated phosphoprotein
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Gene Symbols: Fyb1
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Molecular weight:
90,055 Da
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Basal Isoelectric point:
6.55
Predict pI for various phosphorylation states
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CST Pathways:
T Cell Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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