SLAP-130 Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 15|15 A1
Cellular Component:  actin cytoskeleton; cell junction; cytoplasm; nucleus; plasma membrane
Molecular Function:  lipid binding; protein binding; protein-containing complex binding
Biological Process:  immune response; integrin-mediated signaling pathway; protein localization to plasma membrane; T cell receptor signaling pathway
Reference #:  O35601 (UniProtKB)
Alt. Names/Synonyms: ADAP; Adhesion and degranulation promoting adaptor protein; B630013F22Rik; Fyb; FYB-120/130; FYB1; FYN binding protein; FYN binding protein FYB-130; FYN-binding protein; FYN-binding protein 1; FYN-T-binding protein; p120/130; p120/p130; SLAP-130; SLAP130; SLP-76-associated phosphoprotein
Gene Symbols: Fyb
Molecular weight: 90,055 Da
Basal Isoelectric point: 6.55  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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SLAP-130

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene