EPCR Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation. Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 2|2 H1
Cellular Component:  centrosome; extracellular space; integral component of membrane; membrane; perinuclear region of cytoplasm
Molecular Function:  protein C-terminus binding; signaling receptor activity
Biological Process:  blood coagulation; hemostasis; negative regulation of coagulation
Reference #:  Q64695 (UniProtKB)
Alt. Names/Synonyms: Activated protein C receptor; AI325044; APC receptor; Ccc; Ccca; Ccd41; CD antigen CD201; CD201; Centrocyclin; Centrosomal protein CCD41; Endothelial cell protein C receptor; Endothelial protein C receptor; Epcr; OTTMUSP00000017260; Procr; protein C receptor, endothelial
Gene Symbols: Procr
Molecular weight: 27,189 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene