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REV3
Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. Belongs to the DNA polymerase type-B family. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA replication; EC 2.7.7.7; Transferase |
| Chromosomal Location of Human Ortholog: 10|10 B1 |
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Cellular Component:
nucleolus; nucleus; zeta DNA polymerase complex
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Molecular Function:
4 iron, 4 sulfur cluster binding; DNA binding; DNA-directed DNA polymerase activity; iron-sulfur cluster binding; metal ion binding; nucleic acid binding; nucleotide binding; nucleotidyltransferase activity; transferase activity
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Biological Process:
cellular response to DNA damage stimulus; DNA repair; DNA replication; error-prone translesion synthesis; translesion synthesis
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Reference #:
Q61493
(UniProtKB)
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Alt. Names/Synonyms: DNA polymerase zeta catalytic subunit; DPOLZ; Polz; Protein reversionless 3-like; Rev; Rev3; REV3 like, DNA directed polymerase zeta catalytic subunit; REV3-like; REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like; REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like (S. cerevisiae); Rev3l; Seizure-related protein 4; Sez; Sez4
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Gene Symbols: Rev3l
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Molecular weight:
350,711 Da
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Basal Isoelectric point:
8.61
Predict pI for various phosphorylation states
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