REV3 Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. Belongs to the DNA polymerase type-B family. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA replication; EC; Transferase
Chromosomal Location of Human Ortholog: 10|10 B1
Cellular Component:  nucleolus; nucleus; zeta DNA polymerase complex
Molecular Function:  4 iron, 4 sulfur cluster binding; DNA binding; DNA-directed DNA polymerase activity; iron-sulfur cluster binding; metal ion binding; nucleic acid binding; nucleotide binding; nucleotidyltransferase activity; transferase activity
Biological Process:  cellular response to DNA damage stimulus; DNA repair; DNA replication; error-prone translesion synthesis; translesion synthesis
Reference #:  Q61493 (UniProtKB)
Alt. Names/Synonyms: DNA polymerase zeta catalytic subunit; DPOLZ; Polz; Protein reversionless 3-like; Rev; Rev3; REV3 like, DNA directed polymerase zeta catalytic subunit; REV3-like; REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like; REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like (S. cerevisiae); Rev3l; Seizure-related protein 4; Sez; Sez4
Gene Symbols: Rev3l
Molecular weight: 350,711 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene