ADD2 Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. Belongs to the aldolase class II family. Adducin subfamily. Expressed mainly in brain, spleen, kidney cortex and medulla, and heart. Also expressed in human umbilical vein endothelial cells, human vascular smooth muscle cells, kidney tubular cells and K-562 cell line. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of rat Ortholog: 4q34
Cellular Component:  cytoplasmic vesicle; cytoskeleton; F-actin capping protein complex; glutamatergic synapse; membrane; plasma membrane raft; postsynapse; postsynaptic density
Molecular Function:  actin binding; actin filament binding; calmodulin binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; spectrin binding; structural constituent of cytoskeleton; structural molecule activity
Biological Process:  actin filament bundle assembly; barbed-end actin filament capping; hemopoiesis; ion transport; leukocyte migration; leukocyte tethering or rolling; positive regulation of protein binding; protein-containing complex assembly; synapse assembly
Reference #:  Q05764 (UniProtKB)
Alt. Names/Synonyms: Add2; ADDB; adducin 2 (beta); adducin beta; Adducin-63; beta-ADD; Beta-adducin; Erythrocyte adducin subunit beta
Gene Symbols: Add2
Molecular weight: 80,593 Da
Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene