ABCD3 Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity. Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, ABC family
Chromosomal Location of rat Ortholog: 2q41
Cellular Component:  intracellular membrane-bounded organelle; membrane; mitochondrion; peroxisomal matrix; peroxisomal membrane; peroxisome
Molecular Function:  ABC-type transporter activity; acyl-CoA hydrolase activity; ATP binding; ATP hydrolysis activity; ATPase-coupled transmembrane transporter activity; long-chain fatty acid transporter activity; protein binding; protein homodimerization activity; protein self-association
Biological Process:  bile acid and bile salt transport; bile acid biosynthetic process; fatty acid beta-oxidation; fatty acid biosynthetic process; lipid transport; long-chain fatty acid import into peroxisome; peroxisome organization; phytanic acid metabolic process; response to organic cyclic compound; response to xenobiotic stimulus; transmembrane transport; very long-chain fatty acid catabolic process; very long-chain fatty acid metabolic process
Reference #:  P16970 (UniProtKB)
Alt. Names/Synonyms: 70 kDa peroxisomal membrane protein; 70-kDa peroxisomal membrane protein; Abcd3; ATP-binding cassette sub-family D member 3; ATP-binding cassette, sub-family D (ALD), member 3; Peroxisomal membrane protein 1; PMP70; Pxmp1
Gene Symbols: Abcd3
Molecular weight: 75,316 Da
Basal Isoelectric point: 9.32  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene